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Lymphoma Gobbles HDL Cholesterol

January 27th 2013 02:31
Recent studies have shown that B-cell lymphoma is dependent on the uptake of natural HDL -- short for high-density lipoprotein -- from which it derives fat content, such as cholesterol.

The nanoparticle -- originally developed by Thaxton as a possible therapy for heart disease -- closely mimics the size, shape and surface chemistry of natural HDL particles. But it has one key difference: a five nanometer gold particle at its core. Thus, when the nanoparticle is incubated with human B-cell lymphoma cells or used to treat a mouse with the human tumor, it socks lymphoma with a double whammy. After it attaches to the lymphoma cell, the gold particle's spongy surface sucks out its cholesterol while the gold core prevents the cell from absorbing more cholesterol typically carried in the core of natural HDL particles.


The lymphoma research showed Thaxton that the HDL nanoparticle had more than one trick up its golden sleeve.
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