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Body’s Immune System Enlisted to Fight Cancer

September 15th 2008 15:00
Antibodies' recognition of and attachment to cell proteins
City of Hope - Link

It seems these days that cancer has become a pervasive and uniquely devastating disease. While many new treatments are being researched, chemotherapy and radiation remain at the fore of treatment options. Although still in clinical trials, City of Hope is attempting to circumvent the use of these devastating treatments with a better one: immunotherapy. This technique is elegant in that it pushes the body to do what it should be doing on its own, fight the cancer. The immune system is usually triggered when it recognizes something different, or foreign in the body. These foreign objects, whether bacterial, viral proteins or something else, are marked as “non-self”, or not natural to the human body, and are destroyed. Unfortunately, what makes the immune system so effective also causes its downfall when it comes to cancer. Since cancer is caused by the body’s own cells losing control and replicating nonstop, nothing is foreign. There is nothing to trigger the immune system to say, “this doesn’t belong”. The cells do belong, there are just too many of them, allowing the defense system to remain dormant.

Immunotherapy tries to correct this by forcing the immune system to recognize and attack the unruly proliferation of cells. Although there are several ways to accomplish this, one way uses antibodies developed specifically to a protein made only by cancer cells. Once a patient has been given these antibodies, they circulate through the body and are drawn, like magnets, to the cancer cells and the proteins they make. Like magnets of opposite polarity, the antibody and protein latch on to one another. In essence, this marks the cancer cell and stimulates the body’s immune system. This antibody marking allows the immune system to finally “see” the cancer cells. When this occurs, the cancer cells can be destroyed exclusively, without harming adjacent healthy, normal cells.


While several immunotherapy techniques of this sort are still in clinical trials, the possibility of a cancer-cure seems closer than ever. Within a few years or the next decade, cancer may become a domesticated problem rather than a feral beast.

Source: Scientific American Special Edition, September 2008, Vol 18, Num 3
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